Characterizing Protein Aggregation With Orthogonal and Complementary Analytical Techniques

Protein aggregates span nanometers to visible particles—and no single instrument covers that whole range. This white paper shows how combining flow imaging microscopy, submicron FIM, light obscuration, and DLS builds a complete picture of particle content in biotherapeutic formulations.

What's inside:

• Why orthogonal and complementary techniques are necessary to characterize particles across the full size range
• A BSA stress study comparing shaking vs. heat stress, with and without polysorbate 80
• Head-to-head data from FlowCam LO, FlowCam Nano, and DLS across four analytical modalities
• How surfactant dramatically reduced shaking-induced aggregation but had limited effect on heat-induced aggregates
• Why translucent protein aggregates challenge light obscuration—and how FIM fills the gap
• How two FlowCam instruments extend the particle information available from traditional FIM

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