Flow Imaging Microscopy for Monitoring Particles in Gene Therapies

Speaker:  Austin Daniels, PhD
Yokogawa Fluid Imaging Technologies

Duration:  60 Minutes

Flow imaging microscopy (FIM) is a common analytical technique for monitoring subvisible particles in biotherapeutics. This webinar introduces FIM and discusses how it can be used to monitor subvisible particles in gene therapy drug products. We also present a case study in which FIM was used to analyze AAV formulations during an accelerated stability study. These measurements were used to investigate the impact of formulation ionic strength and different accelerated stability stresses on AAV aggregation. Applications for monitoring subvisible particles in other types of gene therapies are also discussed.

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