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Flow Imaging Microscopy for Subvisible Particle Analysis in Protein and Cell & Gene Therapies

Speaker:  Austin Daniels, PhD, Application Scientist, Yokogawa Fluid Imaging Technologies

Duration:  60 Minutes

This webinar discusses how Flow Imaging Microscopy (FIM) instruments can help characterize particle impurities in different biotherapeutic platforms when paired with orthogonal and complementary analytical techniques. The session primarily focuses on a case study in which FIM and complementary particle analysis techniques including light obscuration (LO) and dynamic light scattering (DLS) were used to analyze particles in protein formulations. These measurements were used to determine the impact of stress conditions and surfactants on protein aggregation during an accelerated stability study. Strategies for monitoring cells, viral vector aggregates, and other particles encountered in cell and gene therapy samples are also discussed.

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