One instrument. One sample run. Two analytical methods. 

  • Correlate light obscuration data with flow imaging microscopy.
  • Reconcile data from a single sample, and a single run with two different technologies.
  • Save time and sample quantities by using a single instrument.
  • Obtain full particle characterization and improved sample throughput time in a single step.

Watch our video to learn more about the new FlowCam LO:

LO sales demo - new

 

FlowCam LO white paper thumbnail

Use the form on this page to download our White Paper:
Measuring Subvisible Particles and Aggregates Using FlowCam LO.

Measuring and monitoring particulate matter present in injectable drugs is crucial to companies involved in formulation development, manufacturing, and packaging of biopharmaceuticals. Adverse effects caused by protein aggregates and extrinsic particles in these drugs have been well documented over the years. The risks range from reduced efficacy to significant immunogenic responses.

While analysis using light obscuration instrumentation is standard, the FDA has long made clear that size data alone, collected with light obscuration, is not adequate to ensure safe and effective drugs, and that it is also necessary to provide validation and imaging data using orthogonal methods.

FlowCam LO combines both light obscuration and flow imaging in a single instrument.

What early adopters of the FlowCam LO are saying:

"Our process involves generating highly loaded protein microparticles. We use the FlowCam LO to analyze all of these sample types...The FlowCam LO has already enhanced & modernized our SVP profiling. Needless to say we have much greater confidence in the data it provides compared to the PV-100!"
- Analytical Development Lead at US Biopharmaceutical Company

"In [Flow Imaging Microscopy], the fast acquisition electronics + high quality optics appear better at detecting our materials which are protein-based therapeutics. This tallies with what has been observed in the literature. LO is the compendial method however I have reservations about it’s ability to detect translucent protein particles whose RI is similar to the aqueous medium in which they reside. LO also cannot allow you to perform post-experiment image analysis or to distinguish one species from another (bubble and particle may appear the same)."
- Development Scientist at one of the ten largest Biopharma
companies worldwide